Ultrasonic backscatter coefficient quantitative estimates from Chinese hamster ovary cell pellet biophantoms
نویسندگان
چکیده
منابع مشابه
Ultrasonic backscatter coefficient quantitative estimates from high-concentration Chinese Hamster Ovary cell pellet biophantoms.
Previous work estimated the ultrasonic backscatter coefficient (BSC) from low-concentration (volume density <3%) Chinese Hamster Ovary (CHO, 6.7-μm cell radius) cell pellets. This study extends the work to higher cell concentrations (volume densities: 9.6% to 63%). At low concentration, BSC magnitude is proportional to the cell concentration and BSC frequency dependency is independent of cell c...
متن کاملUltrasonic backscatter coefficient quantitative estimates from Chinese hamster ovary cell pellet biophantoms.
A cell pellet biophantom technique is introduced, and applied to the ultrasonic backscatter coefficient (BSC) estimate using Chinese hamster ovary (CHO) cells. Also introduced is a concentric sphere scattering model because of its geometrical similarities to cells with a nucleus. BSC comparisons were made between the concentric sphere model and other well-understood models for mathematical veri...
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ii ABSTRACT This dissertation investigates the ultrasonic scattering from tumors. Tumors are complex acoustic scattering media and to date there has not been an adequate acoustic scattering model that fits them well. The tumor scattering mechanisms are studied herein by a step-wise approach: starting from simple (low-concentration cell pellet biophantoms) to moderately complex (high-concentrati...
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Ultrasonic backscatter coefficient (BSC) measurements were performed on K562 cell pellet biophantoms with cell concentrations ranging from 0.006 to 0.30 in the 10-42 MHz frequency bandwidth. Three scattering models, namely, the fluid-filled sphere model (FFSM), the particle model (PM), and the structure factor model (SFM), were compared for modeling the scattering from an ensemble of concentrat...
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Propranolol (PL), a non-selective beta-blocker, is a cardiovascular drug widely used to treat hypertension. The present study was concerned with assessing the cytogenetic effects of this drug on Chinese hamster ovary (CHO) cell line. MTT assay was then carried out to determine the cytotoxicity index (IC50) of the drug. The IC50 value of PL was 0.43±0.02 mM. To investigate the clastogenic effect...
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ژورنال
عنوان ژورنال: The Journal of the Acoustical Society of America
سال: 2010
ISSN: 0001-4966
DOI: 10.1121/1.3483740